Yes it does , having personally witnessed tradesmen who build the same thing the same way everyday suddenly deviate after years of repetition and have no recall or explanation , it is us who are the constant in the equation . From gmo's in our food to high fructose corn syrup in everything to genetically engineered animals that are stuffed full of antibiotics and steroids and growth hormones which we all consume as well petro chemicals used as a base for some foods and also as artificial fertilizers , meat that is actually soaked in ammonia to "cleanse " it then packaged and sold to us . Our entire food chain is damaged , add in the high levels of radiation due to reactor meltdowns that we know of . The list of possible and potential damaging factors that could affect our brain function not to mention the effect of time itself wear and tear as well as replicative fade and error as our cells replace themselves also the factor that our brains do not regenerate as such due to how nerve cells die off and are not replenished . Myself I am 47 and have noticed a decrease in mental acuity and reaction times from when I was much younger , I understand you are senior to me . I do not question your faculties on the contrary I respect a lot , while I like to entertain in passing the concepts of multiple universes and timelines until we can find chronotons and isolate the waves that they compose in order to travel in multiple directions I an skeptical . I was although quite happy when they isolated graviton waves recently .
The constant is that there is no constant , the universe is dynamic and ever changing , so hence change is the constant.